antidepressant, depression, antidepressant drug, mao inhibitor, antidepressant

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WHAT IS THE ROLE OF MAO IN DEPRESSION? CAN GH3 CORRECT IT AS AN ANTIDEPRESSANT?

The neurotransmitters serotonin and noreprinephrine apparently are needed for proper neural responses. Most researchers believe that deficient levels result in depressive syndromes. This soon leads to fatigue pessimism, withdrawal and inadequate functioning. MAO is believed to metabolise these neurotransmitters so they will not become too prominent. If they were, it might result in excess neural firing and "manic" behaviour. Conversely, if MAO builds up to a higher level, there may be a deficit of neurotransmitters as the MAO does its job too well. GH3`s reported capacity to balance MAO action may reduce the problem. In contrast to many MAO inhibitors (where a tyramine-restricted diet is needed) Gerovital GH3 acts as a reversible inhibitor of MAO. It isolates the MAO from the neurotransmitters and thus prevents there over metabolisation. Under stress or in the presence of tyramine, the procaine reverses this action so the MAO can perform its other necessary functions.

"We have found procaine to be an effective inhibitor of MAO and to be clinically effective in alleviating depression and reducing psychotic symptoms associated with schizophrenia"
(Rockland State Hospital: Bucci/Saunders)

GH3 has been shown to be a more potent inhibitor of MAO, than procaine. This mode actions in marked contrast to that exhibited by other inhibitors of MAO, that are used clinically for the treatment of depression and hypertension. For example it has been demonstrated that Eutonyl and Nardil and Parnate are IRREVERSIBLE inhibitors of MAO, and it has been widely reported that patients given IRREVERSIBLE inhibitors of MAO may experience hypertensive reactions manifested by Chest pains, Headaches, Fatal Intercranial Haemorrhages particularly after eating certain foods containing tyramine (cheese and wine) and after ingesting certain commonly used clod remedies.On the other hand, hypertensive reactions have NOT been reported in patients treated with GH3; consequently there are NO RESTRICTIONS on the type of food that may be enjoyed while taking GH3"
(University of Southern California: MacFarlane)

"The weak, reversible fully competitive inhibitor of MAO produced by GH3 is in marked contrast to the potent, irreversible inhibition of MAO produced by currently available agents. The mechanism by which GH3 inhibits MAO may help to explain the absence of severe adverse reaction with GH3 that is traditionally associated with irreversible (antidepressant drugs) MAO inhibitors".
(USC: MacFarlane/Besbris)

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